Post‐GWAS Polygenic Risk Score: Utility and Challenges

PRSice: Polygenic Risk Score software

SUMMARY A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in un...

Schizophrenia polygenic risk score and psychotic risk detection.

Predicting Alzheimer's disease: a polygenic hazard score.

the genetic factors that influence the development of alzheimer’s disease (ad) have been the subject of large international collaborative studies in recent years involving many thousands of patients and controls. genome wide association screens (gWas) have produced large datasets which include not only genetic linkage information but also clinical material such as age of disease onset and, in s...

The Correlation between Inflammatory Biomarkers and Polygenic Risk Score in Alzheimer's Disease.

Plasma biomarkers to aid the early diagnosis of Alzheimer's disease (AD) or to monitor disease progression have long been sought and continue to be widely studied. Biomarkers that correlate with AD polygenic risk score, a measure of the polygenic architecture of the disease and highly predictive of AD status, would be excellent candidates. Therefore, we undertook a preliminary study to assess t...

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

BACKGROUND Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. METHODS AND FINDINGS Using genotype data from 17,008 AD cases and 37,154 controls from the International ...